[摘要] 目的 分析颅脑外伤术后颅内感染的因素。 方法 我院2012年11月~ 2013年11月诊治的颅脑外伤术后颅内感染患者80例作为研究对象,采用回顾性的方式分析患者的临床资料,分析感染相关因素。 结果 研究结果显示,感染单因素主要包括患者的年龄、术前GCS评分、手术时间、脑室外引流、术后切口脑脊液漏、开放性伤口,通过logistic多因素回归分析发现,术后颅内感染的高危因素主要为脑室外引流、脑脊液漏、手术时间。 结论 颅脑外伤术后颅内感染因素众多,而脑脊液漏、手术时间、脑室外引流为其独立危险因素,需引起临床人员的重视,在开展颅脑外伤术过程中及早采取有效的预防措施,降低感染发生率,提高手术治疗效果。 [关键词]颅脑外伤;颅内感染;因素 [中图分类号] R651.1 [文献标识码] B [文章编号] 2095-0616(2015)02-161-03 Factors analysis of intracranial infection in 80 patients with craniocerebral trauma operation LIU Shenghua YAO Qingning TANG Xielin LI Qianke ZHAO Chao ZHONG Jun XIAO Kui Department of Neurosurgery, Santai County People's Hospital,Santai Hospital Affiliated to North Sichuan Medical College, Santai 621100, China [Abstract] Objective To analyze the factors of intracranial infection after craniocerebral trauma operation. Methods Retrospectively analyzed the clinical data and the factors of intracranial infection of patients with craniocerebral trauma operation who were selected in our hospital from November 2012 to November 2013. Results It was show that, the single factors of infection were the patient’s age, the preoperative GCS score, the operation time, the external ventricular drainage, the postoperative cerebrospinal fluid leakage and open wound, the high risk factors which were analyzed by multiple regression, were the external ventricular drainage, the cerebrospinal fluid leakage and the operation time. Conclusion It is important that, to pay attention to the factors of intracranial infection which were the cerebrospinal fluid leakage, the operation time and the cerebrospinal fluid leakage, to take effective preventive measures to reduce the incidence of infection and to improve the effect of operation treatment in the process of craniocerebral trauma operation. [Key words] Craniocerebral trauma; Intracranial infection; Factors 临床表明,颅内感染是颅脑外伤术后的严重并发症,对治疗效果和预后造成了严重的影响,甚至威胁到患者的生命安全。因此,在开展颅脑外伤术过程中掌握感染影响因素并及早采取有效的防御措施至关重要[1-2]。本研究分析颅脑外伤术后颅内感染的因素,对我院2012年11月~2013年11月诊治的80例颅脑外伤术后颅内感染患者的临床资料进行了回顾性分析,现报道如下。 1 资料与方法 1.1 一般资料 收集我院2012年11月~2013年11月诊治的80例颅脑外伤术后颅内感染患者,本组患者中男 46例,女34例,年龄19~80岁,平均(57.3±15.2)岁。患者通过脑脊液检查:白细胞均超过10×108/L,蛋白定量超过 2200mg/L,糖定量低于1.9mmol/L,脑脊液浑浊。 1.2 方法 收集患者的临床资料,主要通过查阅患者的住院病历资料,搜集患者的年龄、性别、手术时间、术前GCS评分等,同时对单因素和logistic多因素回归分析比较。 1.3 统计学方法 运用SPSS17.0统计软件加以分析,计量资料使用()表示,并应用配对t检验;计数资料使用x2检验,对变量赋值行logistic多因素回归分析,P<0.05为差异有统计学意义。 2 结果 研究结果显示,感染单因素主要包括患者的年龄、术前GCS评分、手术时间、脑室外引流、术后切口脑脊液漏、开放性伤口,通过logistic多因素回归分析发现,术后颅内感染的高危因素主要为脑室外引流、脑脊液漏、手术时间。见表1~2。 |